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Sheba Microbiome Innovation Center

Host: microbiome interactions are increasingly recognized as important for human health and disease and are the focus of intensive research and clinical efforts in recent years.

As part of this effort, we opened the Sheba Microbiome Innovation Center.

 

We aim to understand host: microbial interactions in health and disease

Use it to prevent, diagnose, and predict disease course

Use it as potential future knowledgeable intervention

We have multiple projects in collboration with other in and outside Sheba and some examples are highligthed below.

Pancreatic
cancer

Lung
cancer

Blindness

Hyper tension

COVID-19

Diabetes

Crohn

dbBact

Bacterial knowledge-base

(manuscript in preparation)

dbBact microorganism knowledge base

Calour

A python module for interactive heatmap analysis of microbiome experiments.

Publication: "Calour: an Interactive, Microbe-Centric Analysis Tool"

EZCalour

User-friendly GUI for Calour

EZCalour A python module for interactive heatmap analysis of microbiome experiments.

Deblur

A sub-OTU Denoising tool for 16S rRNA sequencing processing.

(Also available as a              plugin )

Publication: "Deblur Rapidly Resolves Single-Nucleotide Community Sequence Patterns"

qiime2

dsFDR

Discrete multiple hypothesis correction for microbiome analysis.

Publication: "Discrete False-Discovery Rate Improves Identification of Differentially Abundant Microbes"

Tools

Tools
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