Sheba Microbiome Innovation Center
Host: microbiome interactions are increasingly recognized as important for human health and disease and are the focus of intensive research and clinical efforts in recent years.
As part of this effort, we opened the Sheba Microbiome Innovation Center.
We aim to understand host: microbial interactions in health and disease
Use it to prevent, diagnose, and predict disease course
Use it as potential future knowledgeable intervention
We have multiple projects in collboration with other in and outside Sheba and some examples are highligthed below.
Pancreatic
cancer
Lung
cancer
Blindness
Hyper tension
COVID-19
Diabetes
Crohn
Calour
A python module for interactive heatmap analysis of microbiome experiments.
Publication: "Calour: an Interactive, Microbe-Centric Analysis Tool"
EZCalour
User-friendly GUI for Calour
A sub-OTU Denoising tool for 16S rRNA sequencing processing.
(Also available as a plugin )
Publication: "Deblur Rapidly Resolves Single-Nucleotide Community Sequence Patterns"
Discrete multiple hypothesis correction for microbiome analysis.
Publication: "Discrete False-Discovery Rate Improves Identification of Differentially Abundant Microbes"